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Semaglutide and Renal Health: Hope for Diabetic Kidney Disease Patients

Endocrinology - Diabetes

Diabetic kidney disease (DKD), a significant vascular complication associated with diabetes, is acknowledged as a major global health concern and the key reason for end-stage renal disease. Effective management of blood glucose concentration is essential for treating DKD, as the degree of glucose control directly influences the development of the disease. Using renin-angiotensin-aldosterone inhibitors to regulate blood pressure has demonstrated protective benefits against DKD. The GLP-1RA are among the newest treatment options for managing diabetes and slowing the progression of DKD. A recent clinical study evaluated the safety and efficacy of semaglutide in DKD. The findings of the study resulted in a decrease in eGFR levels in patients with DKD with moderate renal impairment .1 Discussed below is one such case:

  • A 53-year-old man, with a body mass index (BMI) of 36.5 kg/m2 and an HbA1c level of 8.5%, was diagnosed with diabetes mellitus 5 years ago. 
  • Initially, the patient was administered insulin detemir (32 IU), repaglinide (3 mg/day), and linagliptin (5 mg/day).
  • The estimated glomerular filtration rate (eGFR) was 34.6 mL/min/1.73m2
  • Discontinued repaglinide and linagliptin.

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